switches.ELM

Predicted switches in the ELMs Resource

General :Overview Visualisation Statistics

Subsets

Avidity : Avidity-sensing

Specificity : Altered binding specificity Competition Domain hiding Motif hiding

Cumulative : Rheostatic

Pre-assembly : Composite binding site formation

Binary : Allostery Physicochemical compatibility Pre-translational Defined PTM-induced

Specificity - Altered binding specificity

The balance of the competition for overlapping or adjacent, mutually exclusive interaction interfaces is tipped in favor of one of the interactors by PTM-dependent modulation of the intrinsic affinity of a binding region. Multiple, successive PTMs allow sequential switching of different binding partners in an ordered manner by step-wise alteration of binding specificity.

Accession	Protein	Gene	Motif	Start	Stop	Vis
P31749	RAC-alpha serine/threonine-protein kinase	AKT1	LIG_AGCK_PIF_1	469	474	view
P16471	Prolactin receptor	PRLR	LIG_SH2_STAT5	342	345	view
P16471	Prolactin receptor	PRLR	LIG_SCF-TrCP1_1	348	353	view
P06400	Retinoblastoma-associated protein	RB1	LIG_CYCLIN_1	873	877	view
P06400	Retinoblastoma-associated protein	RB1	TRG_NLS_Bipartite_1	860	877	view
P06400	Retinoblastoma-associated protein	RB1	LIG_PP1	872	878	view
P05412	Transcription factor AP-1	JUN	LIG_COP1	227	234	view
P05412	Transcription factor AP-1	JUN	LIG_MAPK_1	32	42	view
P05412	Transcription factor AP-1	JUN	LIG_KEPE_3	225	234	view
P05412	Transcription factor AP-1	JUN	LIG_SCF_FBW7_1	236	243	view
P05412	Transcription factor AP-1	JUN	LIG_WW_Pin1_4	60	65	view
Q07954	Prolow-density lipoprotein receptor-related protein 1	LRP1	LIG_PTB_Phospho_1	4501	4507	view
Q07954	Prolow-density lipoprotein receptor-related protein 1	LRP1	LIG_PTB_Apo_2	4467	4474	view
Q07954	Prolow-density lipoprotein receptor-related protein 1	LRP1	LIG_PTB_Apo_2	4501	4508	view
P05106	Integrin beta-3	ITGB3	LIG_PTB_Phospho_1	767	773	view
P05106	Integrin beta-3	ITGB3	LIG_PTB_Phospho_1	779	785	view
P05106	Integrin beta-3	ITGB3	LIG_PTB_Apo_2	767	774	view
P05106	Integrin beta-3	ITGB3	LIG_PTB_Apo_2	779	786	view
Q9P0K1	Disintegrin and metalloproteinase domain-containing protein 22	ADAM22	LIG_14-3-3_3	831	836	view
Q9P0K1	Disintegrin and metalloproteinase domain-containing protein 22	ADAM22	TRG_ER_diArg_1	851	854	view
Q9P0K1	Disintegrin and metalloproteinase domain-containing protein 22	ADAM22	LIG_14-3-3_3	854	859	view
P05107	Integrin beta-2	ITGB2	LIG_PTB_Apo_2	760	767	view
P05107	Integrin beta-2	ITGB2	LIG_14-3-3_3	755	760	view
P08581	Hepatocyte growth factor receptor	MET	LIG_SH2_SRC	1349	1352	view
P08581	Hepatocyte growth factor receptor	MET	LIG_SH2_SRC	1356	1359	view
P08581	Hepatocyte growth factor receptor	MET	LIG_SH2_GRB2	1356	1359	view
P05067	Amyloid beta A4 protein	APP	LIG_PTB_Apo_2	756	763	view
P05067	Amyloid beta A4 protein	APP	LIG_SH2_GRB2	757	760	view
P05067	Amyloid beta A4 protein	APP	LIG_WW_Pin1_4	740	745	view
Q14118	Dystroglycan	DAG1	LIG_WW_1	889	892	view
P04233	HLA class II histocompatibility antigen gamma chain	CD74	TRG_LysEnd_APsAcLL_1	19	24	view
P04233	HLA class II histocompatibility antigen gamma chain	CD74	TRG_ER_diArg_1	3	5	view
P04233	HLA class II histocompatibility antigen gamma chain	CD74	LIG_14-3-3_3	5	10	view
P09793	Cytotoxic T-lymphocyte protein 4	Ctla4	TRG_ENDOCYTIC_2	201	204	view
P00533	Epidermal growth factor receptor	EGFR	LIG_SH2_SRC	1016	1019	view
P00533	Epidermal growth factor receptor	EGFR	LIG_SH2_SRC	1125	1128	view
P00533	Epidermal growth factor receptor	EGFR	TRG_ENDOCYTIC_2	998	1001	view
P00533	Epidermal growth factor receptor	EGFR	LIG_PTB_Phospho_1	1104	1110	view
P04637	Cellular tumor antigen p53	TP53	LIG_CYCLIN_1	381	385	view
P04637	Cellular tumor antigen p53	TP53	LIG_MDM2	19	26	view
P04637	Cellular tumor antigen p53	TP53	TRG_NES_CRM1_1	339	352	view
P04637	Cellular tumor antigen p53	TP53	LIG_USP7_1	359	363	view
P04637	Cellular tumor antigen p53	TP53	LIG_USP7_1	364	368	view
P04637	Cellular tumor antigen p53	TP53	TRG_NLS_Bipartite_1	305	323	view
P04637	Cellular tumor antigen p53	TP53	LIG_WW_Pin1_4	30	35	view
P04637	Cellular tumor antigen p53	TP53	LIG_WW_Pin1_4	312	317	view
P14598	Neutrophil cytosol factor 1	NCF1	LIG_SH3_2	363	368	view
P14598	Neutrophil cytosol factor 1	NCF1	LIG_WW_Pin1_4	342	347	view
P54253	Ataxin-1	ATXN1	LIG_14-3-3_1	772	777	view
P54253	Ataxin-1	ATXN1	LIG_ULM_U2AF65_1	770	775	view
P54253	Ataxin-1	ATXN1	TRG_NLS_MonoCore_2	769	774	view
P25942	Tumor necrosis factor receptor superfamily member 5	CD40	LIG_TRAF2_1	250	253	view
P38936	Cyclin-dependent kinase inhibitor 1	CDKN1A	LIG_PCNA_PIPBox_1	144	153	view
P38936	Cyclin-dependent kinase inhibitor 1	CDKN1A	LIG_CRL4_Cdt2_1	145	157	view
P38936	Cyclin-dependent kinase inhibitor 1	CDKN1A	TRG_NLS_Bipartite_1	142	158	view
Q15303	Receptor tyrosine-protein kinase erbB-4	ERBB4	LIG_WW_1	1053	1056	view
P01106	Myc proto-oncogene protein	MYC	LIG_SCF_FBW7_1	55	62	view
P01106	Myc proto-oncogene protein	MYC	LIG_WW_Pin1_4	55	60	view
P01106	Myc proto-oncogene protein	MYC	LIG_SH3_2	60	65	view
P30307	M-phase inducer phosphatase 3	CDC25C	LIG_14-3-3_3	213	218	view
P30307	M-phase inducer phosphatase 3	CDC25C	LIG_14-3-3_3	213	218	view
P30307	M-phase inducer phosphatase 3	CDC25C	TRG_NES_CRM1_1	189	203	view
Q9BVK6	Transmembrane emp24 domain-containing protein 9	TMED9	TRG_ER_diLys_1	232	235	view
Q9BVK6	Transmembrane emp24 domain-containing protein 9	TMED9	TRG_Golgi_diPhe_1	221	235	view
O15350	Tumor protein p73	TP73	TRG_NLS_Bipartite_1	327	349	view